However, in states of physiological stress, dehydration, decreased
cardiac output,
existing kidney disease, and old age, prostaglandins are extremely important to ensure
an adequate blood supply to the kidneys, and the inhibition of such can result in a
significant reduction in the blood supply to the kidneys, a phenomenon known as acute
kidney injury, which can occur in a matter of hours from the time the
drug was ingested

Over a decade ago I had been sick and dehydrated, I ended up in the ER with severe rib pain when trying to breath, they gave me an anti-inflammatory intravenously. Less than 12 hours later I was back in the ER with kidney failure. It was acute and considered medically educed. While I no longer take pain meds in part due to that experience, I'd say in general with any medication I am more careful to read the label and or question the potential side effects prior to consuming it.

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On 3/31/2026 4:50 PM, The Godfather wrote to Mike Dippel:

Over a decade ago I had been sick and dehydrated, I ended up in the ER with severe rib pain when trying to breath, they gave me an anti-inflammatory intravenously. Less than 12 hours later I was back in the ER with kidney failure. It was acute and considered medically educed. While I no longer take
pain meds in part due to that experience, I'd say in general with any medication I am more careful to read the label and or question the potential side effects prior to consuming it.

Thanks for sharing.

I sometimes ask the pharmacist when I am picking up and new prescription to explain
the med and ask what time of day it should be taken, as well as does this medication
conflict with the other meds.

You can never know too much when ir comes to prescription drugs.

BTW. Welcome back. It's been a while.

Mike Dippel

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I sometimes ask the pharmacist when I am picking up and new prescription to explain
the med and ask what time of day it should be taken, as well as does this medication
conflict with the other meds.

Yes, hard lesson learned for sure :)

Have you heard of the new DNA test that MD's can do, that tell them what medications a patient can properly metabolize, what meds work versus don't with each patient .. etc?

I think it's called bluegene's ...

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On 4/5/2026 6:24 PM, The Godfather wrote to Mike Dippel:

I sometimes ask the pharmacist when I am picking up and new prescription
to explain
the med and ask what time of day it should be taken, as well as does this
medication
conflict with the other meds.

Yes, hard lesson learned for sure :)

Have you heard of the new DNA test that MD's can do, that tell them what medications a patient can properly metabolize, what meds work versus don't with
each patient .. etc?

I think it's called bluegene's ...

I looked it up. Interesting. You may have helped others with this post. Thanks.

Mike Dippel

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* Origin: The Hobby Line! BBS (999:1/1)

I looked it up. Interesting. You may have helped others with this
post. Thanks.

My wife recently had the test done, we are awaiting the results. Through her school (she's a teacher) they get the test for free. I hope it's helpful for you and yours also :)

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